The San Francisco 49ers (4-1) are on the road in Week 6 to face the Tampa Bay Buccaneers (4-1) at Raymond James Stadium.
Both teams enter with identical records, making this a marquee NFC matchup. The 49ers have dealt with key injuries across their offense, while Tampa Bay has maintained momentum behind Baker Mayfield and a resilient offensive group.
Things to Watch
Quarterback health & depth
San Francisco is missing Brock Purdy, who is ruled out, and Ricky Pearsall is also out. Mac Jones is questionable for Sunday. The 49ers will rely on their backup plans to keep the offense moving.
Meanwhile, the Buccaneers’ roster is battered too: Mike Evans, Chris Godwin Jr., and Bucky Irving are all listed as out. Tampa’s depth, especially at receiver, will be tested heavily.
Christian McCaffrey’s usage
With the 49ers’ receiving corps thin, McCaffrey’s dual-threat ability (run and catch) becomes even more critical. He may see elevated volume and playmaking opportunities.
Defensive weaknesses & matchups
Tampa’s defense has shown vulnerabilities, particularly in the secondary. The 49ers will try to exploit matchups and pressure the edge. On the flip side, the Buccaneers will aim to leverage mismatches in the trenches and along the line of scrimmage.
Turnovers & late-game execution
Given both teams’ injuries and roster stress, one crucial turnover or big play could swing momentum. The team that executes better late and stays disciplined should have the advantage.
Injury Report
San Francisco 49ers
QB Brock Purdy — Out (Toe)
WR Ricky Pearsall — Out (Knee)
WR Jordan Watkins — Out (Calf)
DL Yetur Gross-Matos — Out (Knee / Hamstring)
DL Kevin Givens — Out (Hand)
DL Alfred Collins — Questionable (Knee)
DL Kalia Davis — Questionable (Hand)
CB Upton Stout — Questionable (Ankle)
S Malik Mustapha — Questionable (Knee)
WR Jauan Jennings — Questionable (Ankle / Rib)
QB Mac Jones — Questionable (Knee / Oblique)
Tampa Bay Buccaneers
WR Mike Evans — Out (Hamstring)
WR Chris Godwin Jr. — Out (Fibula)
RB Bucky Irving — Out (Foot / Shoulder)
CB Zyon McCollum — Out (Thumb)
CB Benjamin Morrison — Out (Hamstring)
DB Christian Izien — Questionable (Quadriceps)
Predictions
This is a battle of attrition. Tampa’s home field and Mayfield’s recent consistency give them a slight edge. But the 49ers, with McCaffrey and aggressive playcalling, can make this competitive. If San Francisco’s backups at QB and receiver hold up under pressure, they can challenge. Expect a tight finish.
Projected Final Score: Buccaneers 27, 49ers 23
How to Watch 49ers vs. Buccaneers
Kickoff for this afternoon’s game between the San Francisco 49ers and Tampa Bay Buccaneers is set for 4:25 PM Eastern at Raymond James Stadium.
The game airs live on CBS throughout most of the U.S. except for the Midwest.
So fans in those regions can tune in for free on their local CBS affiliate via antenna. CBS is also available at no additional cost through most cable, satellite, and live streaming packages.
Today’s game also streams live on the CBS and CBS Sports apps and websites.
If you’re a cordcutter without a livestreaming subscription, you can watch your regional broadcast for free by signing up for a trial with FuboTV, YouTube TV, Hulu + Live TV, or DirecTV Stream.
You can also stream your local CBS game for free through a Paramount+ trial, available on Amazon here.
YouTube TV also provides a 20-minute free preview without requiring registration.
Fans outside the regional broadcast areas can watch the game on YouTube’s NFL Sunday Ticket, starting at $34.50 per month.
San Francisco 49ers vs. Tampa Bay Buccaneers
Date: Sunday, October 12, 2025
Time: 4:25 PM Eastern
Venue: Raymond James Stadium, Tampa, FL
TV: CBS
Streaming: CBS and CBS Sports app and website
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