The Jacksonville Jaguars (2-1) head out west to face the San Francisco 49ers (3-0) this afternoon for a Week 4 matchup at Levi’s Stadium in Santa Clara.
San Francisco will get Brock Purdy back under center, after missing time with toe and shoulder injuries. Their offense, despite injuries across the roster, leans on Christian McCaffrey, who has piled up 176 rushing yards through the first three weeks, along with steady receiving production, as the centerpiece of their attack.
Jacksonville enters with a strong defense, leading the NFL in takeaways and holding opponents to just 82.7 rushing yards per game. But their offense has been inconsistent. Trevor Lawrence has thrown for 671 yards with four touchdowns and four interceptions across the first three games.
That imbalance gives Purdy’s return extra weight, as the 49ers look to exploit passing matchups against a Jacksonville team that has thrived on turnovers but is still searching for rhythm on the other side of the ball.
4 Things to Watch
1. Purdy’s health & command
Coming back from toe and shoulder injuries, Purdy’s mobility and accuracy will be under pressure. Mac Jones remains an option but is also dealing with a knee issue.
2. San Francisco’s depleted roster, especially in defense
The 49ers are already without Nick Bosa for the season. They also elevated Eli Apple to cover for injuries at cornerback, and receivers Jauan Jennings and Ricky Pearsall are listed as questionable.
3. Jaguars’ run defense vs. McCaffrey
Jacksonville’s run defense is among the best so far; how they contain McCaffrey and force San Francisco to rely more on its passing game could determine the flow.
4. Turnover margin, hidden yardage & situational football
Given both teams’ strengths (Jaguars in takeaways, 49ers in offense when healthy), turnovers, big special teams plays, and fourth-down decisions may tip the balance. Analysts expect a close game, possibly decided by a field goal.
Predictions
Despite San Francisco getting Purdy back, their depth hits and missing studs like Bosa are major handicaps. Jacksonville’s defense is elite this season, and their ability to force turnovers may cancel out San Francisco’s offensive bursts. Expect a tight, low-scoring affair where the Jaguars keep it within one score.
Projected Final Score: Jaguars 23, 49ers 20
Injury Report
Jacksonville Jaguars
WR Dyami Brown — Questionable (Shoulder)
RB Bhayshul Tuten — Questionable (Shoulder)
OL Wyatt Milum — Questionable (Knee)
OL Ezra Cleveland — Questionable (Ankle)
San Francisco 49ers
WR Jordan Watkins — Out (Calf)
DT C.J. West — Out (Thumb)
G Connor Colby — Questionable (Groin)
CB Renardo Green — Questionable (Neck)
WR Jauan Jennings — Questionable (Ankle / Shoulder)
WR Ricky Pearsall — Questionable (Knee)
QB Mac Jones — Questionable (Knee)
How to Watch Jaguars vs. 49ers
Kickoff for this afternoon’s game between the Jacksonville Jaguars and San Francisco 49ers is set for 4:05 PM Eastern / 1:05 PM Pacific at Levi’s Stadium in Santa Clara.
The game airs live on FOX in the Bay Area and Jacksonville markets, as well as across northern California, Oregon, parts of Nevada, as well as the New York City, DC, Atlanta, and Houston markets.
Jacksonville Jaguars vs. San Francisco 49ers
Date: Sunday, September 28, 2025
Time: 4:05 PM Eastern / 1:05 PM Pacific
Venue: Levi’s Stadium, Santa Clara, CA
TV: FOX
Streaming: FOX Sports app and website, NFL+
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