The Arizona Cardinals (2-3) face the Indianapolis Colts (4-1) this afternoon in a Week 6 matchup at Lucas Oil Stadium.
Arizona enters with uncertainty at quarterback: Kyler Murray is questionable due to a foot injury. The Cardinals have elevated Kedon Slovis and prepared Jacoby Brissett in case Murray cannot play.
Meanwhile, the Colts are thriving with a balanced offense and defensive steadiness, led by coach Shane Steichen and an emerging supporting cast.
Things to Watch
Quarterback status in Arizona
Murray’s foot issue clouds the game plan. If he sits, Brissett’s familiarity with Indy could be an intriguing wrinkle and may mitigate disruption.
Colts’ ground game vs. Cardinals run defense
Indianapolis has been effective running the ball, and if the Cardinals stack to stop it, the Colts can open up favorable play-action opportunities.
Arizona’s defensive strength
Despite offensive struggles, Arizona ranks among the better defenses in points allowed. If their pass rush can pressure Daniel Jones and force turnovers, they can stay competitive.
Injury and depth on both rosters
For the Cardinals, several players (WR Zay Jones, CB Max Melton) are questionable. For the Colts, cornerback Kenny Moore II is out with an Achilles injury, and RB Tyler Goodson (groin) is unavailable, elevating Ameer Abdullah in his place.
Matchup in the trenches
Arizona’s front, including edge rusher Josh Sweat, will try to disrupt the Colts’ interior and make life difficult on Jones. If Indianapolis can protect and generate push up front, they’ll control tempo.
Injury Report
Arizona Cardinals
QB Kyler Murray — Questionable (Foot)
DL Darius Robinson — Out (Pectoral)
P Blake Gillikin — Out (Back)
WR Zay Jones — Questionable (Knee)
CB Max Melton — Questionable (Hamstring)
LB Cody Simon — Questionable (Knee)
LB Mack Wilson Sr. — Questionable (Ankle)
Indianapolis Colts
CB Kenny Moore II — Out (Achilles)
RB Tyler Goodson — Out (Groin)
WR Alec Pierce — Available (cleared concussion protocol)
Predictions
With Murray’s status tenuous, the Colts have a clear advantage. Their balanced offense, coaching continuity, and home-field setting give them the edge. Even if Brissett starts, Arizona’s defense and game plan may keep it closer early. But overall, Indianapolis should pull away in the second half.
Projected Final Score: Colts 28, Cardinals 17
How to Watch Cardinals vs. Colts
Kickoff for this afternoon’s game between the Arizona Cardinals and Indianapolis Colts is set for 1:00 PM Eastern at Lucas Oil Stadium.
The game airs live on FOX in Arizona and Indiana.
So fans in those regions can tune in for free on their local FOX affiliate via antenna. FOX is also available at no additional cost through most cable, satellite, and live streaming packages.
Today’s game also streams live on the FOX Sports app and website.
If you’re a cordcutter without a livestreaming subscription, you can watch your regional broadcast for free by signing up for a trial with FuboTV, YouTube TV, Hulu + Live TV, or DirecTV Stream.
YouTube TV also provides a 20-minute free preview without requiring registration.
Fans outside the regional broadcast areas can watch the game on YouTube’s NFL Sunday Ticket, starting at $34.50 per month.
Arizona Cardinals vs. Indianapolis Colts
Date: Sunday, October 12, 2025
Time: 1:00 PM Eastern
Venue: Lucas Oil Stadium, Indianapolis, IN
TV: FOX
Streaming: FOX One and FOX Sports app and website
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