Charlotte (1-3) faces South Florida (3-1) tonight in Week 6 of the 2025 college football season at Raymond James Stadium in Tampa.
This is South Florida’s league opener and a tough test for Charlotte’s rebuilding squad.
USF enters with momentum, having shocked Florida earlier in the season and dominating in nonconference play. Their offense, led by dual-threat QB Byrum Brown, has shown both explosiveness and efficiency, and their defense has delivered big plays and held down opponents.
The Bulls are also coming off a 63-14 rout of South Carolina State in which Brown threw four touchdown passes, RB Sam Franklin ran for two more, and the defense chipped in with a 93-yard pick-six and five sacks. Their lone loss came in a 49-12 defeat at Miami on September 13, when USF managed just two field goals in the first half and added a late touchdown pass from Brown to Christian Neptune in the fourth quarter.
Charlotte, meanwhile, is dealing with significant roster setbacks: starting QB Conner Harrell and veteran RB Henry Rutledge have been ruled out for the season.
The 49ers turned to Duke transfer Grayson Loftis under center, with WRs E. Jai Mason and Javen Nicholas as primary receiving threats. Loftis showed flashes in last week’s 28-17 loss at Rice, throwing for 186 yards and a touchdown, but he was under heavy pressure all night.
The team’s struggles with protection and defensive depth remain their biggest challenges heading into Tampa.
Prediction
South Florida has too many advantages — offensive balance, depth, momentum, and home field. If USF avoids turnovers and maintains tempo, it should control this game from early on. Charlotte may find occasional rhythm, but with its injured roster, it’s hard to see them keeping pace deep.
Projected Score: South Florida 41, Charlotte 10
How to Watch Charlotte vs. South Florida
Kickoff for tonight’s game between Charlotte and South Florida is set for 7:00 PM Eastern at Raymond James Stadium, Tampa, FL.
The game airs on ESPN2 and streams on the ESPN app and website.
If you’re a cord-cutter without an active livestreaming plan, you can watch the game for free by taking advantage of free trials from DIRECTV Stream, Hulu + Live TV, Fubo TV, or YouTube TV.
YouTube TV even offers a 20-minute free preview, without having to register for a trial — if you just want to catch part of the game.
Charlotte 49ers vs. South Florida Bulls
Date: Friday, October 3, 2025
Time: 7:00 PM Eastern
Venue: Raymond James Stadium, Tampa, FL
TV: ESPN2
Streaming: ESPN app and website
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