The San Francisco 49ers (3-1) face the Los Angeles Rams (3-1) in an NFC West battle in tonight’s Week 5 Thursday Night Football game at SoFi Stadium in L.A.

San Francisco will be shorthanded. QB Brock Purdy is out with a turf toe injury, his third missed game this season, leaving Mac Jones to start in his place.

Jones has been more than serviceable in two starts, completing 53 of 80 passes (66.3%) for 563 yards in two San Francisco wins. But the 49ers are also missing wideouts Jauan Jennings, Ricky Pearsall, and Jordan Watkins, along with defensive end Robert Beal Jr., among others.

The Rams’ injury report is comparatively lighter, with tight end Tyler Higbee (hip) and tackle Rob Havenstein (ankle) as doubtful.

The Rams’ offense is rolling, ranked top four in the NFL with 1,589 total yards through the first four weeks. WR Puka Nacua leads the league in receptions (42) and receiving yards, coming off a career-best 170 yards on 13 catches with a touchdown in last week’s win over the Indianapolis Colts — his third game this season with at least 10 receptions and 100 yards.

QB Matthew Stafford, now 37, enters Week 5 ranked in the league’s top 10 in QBR (69.1). He was sharp Sunday against Indianapolis, going 29-of-41 for 375 yards and three touchdowns.

Things to Watch

Jones under center without top weapons

With Purdy out and three receivers sidelined, Jones will need to rely on secondary options. His best targets are RB Christian McCaffrey, WRs Kendrick Bourne, Demarcus Robinson, and Skyy Moore, along with TE Jake Tonge. His ability to stay poised under pressure and distribute the ball efficiently will be crucial.

McCaffrey’s increased burden

McCaffrey must carry more of the offense both on the ground and as a pass catcher. He has 305 receiving yards this season, compared to just 225 rushing yards — averaging 3.3 yards per carry, a career low, with no rushing touchdowns.

Rams’ offensive continuity vs. 49ers’ defensive integrity

The Rams have more stability on offense, while San Francisco’s defense has been stretched thin. How Los Angeles attacks mismatches in coverage will be a key factor.

Line play and pass rush impacts

With Purdy sidelined, the Rams will look to rattle Jones with pressure. The trenches will be decisive, particularly if Havenstein is unavailable. Whoever controls the line of scrimmage will control the tempo.

Injury Report

San Francisco 49ers

QB Brock Purdy — Out (Toe)

WR Jauan Jennings — Out (Ankle / Rib)

WR Ricky Pearsall — Out (Knee)

WR Jordan Watkins — Out (Calf)

DE Robert Beal Jr. — Out (Ankle)

DT C.J. West — Questionable (Thumb)

Los Angeles Rams

TE Tyler Higbee — Doubtful (Hip)

OT Rob Havenstein — Doubtful (Ankle)

OL Steve Avila — Questionable (Ankle)

Predictions

Given San Francisco’s heavy injuries, especially on offense, they enter this matchup at a significant disadvantage. The Rams, with a healthier roster and home field, have multiple paths to exploit mismatches.

If Jones plays smart and the 49ers defense holds firm in the red zone, it’ll be competitive. But Los Angeles has the edge.

Projected Final Score: Rams 27, 49ers 20

How to Watch 49ers vs. Rams

Kickoff for tonight’s game between the San Francisco 49ers and Los Angeles Rams is set for 8:15 PM Eastern / 5:15 PM Pacific at SoFi Stadium, Inglewood, CA.

The game won’t air on television. It’s an Amazon Prime Video Exclusive.

You can watch the game live on Amazon Prime Video here.

If you’re not an Amazon Prime member, you can watch the game for free by signing up for a free 30-day trial here.

San Francisco 49ers vs. Los Angeles Rams

Date: Thursday, October 2, 2025

Time: 8:15 PM Eastern / 5:15 PM Pacific

Venue: SoFi Stadium, Inglewood, CA

TV/Streaming: Amazon Prime Video


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