The New Orleans Saints (0-3) travel to face the Buffalo Bills (3-0) this afternoon at Highmark Stadium in Orchard Park in a battle between the winless and the undefeated.
Buffalo has been sharp to start 2025, piling up 1,260 total yards across three games while spreading the ball efficiently. Josh Allen has completed 69.7% of his passes for 755 yards with 5 touchdowns and no interceptions, aided by a balanced attack.
James Cook leads the ground game with 284 rushing yards and 4 touchdowns, and he’s also active in the passing game. Wideout Keon Coleman (158 yards, 1 TD), tight end Dalton Kincaid (151 yards, 2 TDs), and slot receiver Khalil Shakir (121 yards, 1 TD) have all been reliable targets.
The Saints, by contrast, have struggled to generate consistency. They’ve totaled 906 yards but rank near the bottom of the league in efficiency, averaging only 4.4 yards per play.
The passing game has leaned heavily on Chris Olave (165 yards), Juwan Johnson (176 yards, 1 TD), and Rashid Shaheed (127 yards, 1 TD). Despite Spencer Rattler’s nearly 70% completion rate, the offense has sputtered due to turnovers, penalties, and poor line play.
Buffalo’s defense is missing stalwarts Ed Oliver and Matt Milano, leaving vulnerabilities up front. For New Orleans, a patchwork line with Trevor Penning and rookie Taliese Fuaga is still finding rhythm.
4 Things to Watch
1) Buffalo adjusting without Oliver & Milano
The Bills will be without DT Ed Oliver and LB Matt Milano due to injuries. Their absence weakens the interior of Buffalo’s defense, making it more vulnerable to the Saints’ run and inside passing.
2) Saints’ front line vs. a dominant offense
New Orleans is starting Trevor Penning and Taliese Fuaga after injuries elsewhere. Their ability to protect the quarterback and open lanes for the run is crucial if they hope to stay competitive.
3) Buffalo’s offense in rhythm
The Bills’ offense is among the top in the league in efficiency per play. Even with injuries, they should sustain pressure. The Saints’ defense, especially the secondary, will need to force turnovers or big stops to stay in it.
4) Saints’ desperation factor & game pace
New Orleans must play with urgency: typically, second-half comebacks won’t suffice here. The pace and turnovers will likely decide whether they can hang in or get overrun.
Injury Report
New Orleans Saints
DE Chase Young — Out
OL Dillon Radunz — Out
WR Devaughn Vele — Questionable
T Taliese Fuaga — Available
LG Trevor Penning — Available
DE Cameron Jordan — Available
Buffalo Bills
DT Ed Oliver — Out
LB Matt Milano — Out
OL Spencer Brown — Questionable
DE A.J. Epenesa — Questionable
Predictions
Even with missing defensive starters, the Bills still hold a major advantage. Their offense is fluid, and the Saints are thin on defense and struggling to build momentum. If Buffalo controls the line of scrimmage and avoids turnovers, they should pull away. But if New Orleans can land early punches and make Buffalo pay for mistakes, it might stay closer.
Projected Final Score: Bills 34, Saints 17
How to Watch Saints vs. Bills
Kickoff for today’s game between the New Orleans Saints and Buffalo Bills is set for 1:00 PM Eastern at Highmark Stadium, Orchard Park, NY.
The game airs live on CBS in the Buffalo and New Orleans markets as well as upstate New York, New England, western Pennsylvania, Ohio, Louisiana, and South Florida.
So fans in those regions can tune in for free on their local CBS affiliate via antenna. CBS is also available at no additional cost through most cable, satellite, and live streaming packages.
Today’s game also streams live on the CBS and CBS Sports apps and websites.
If you’re a cordcutter without a livestreaming subscription, you can watch your regional broadcast for free by signing up for a trial with FuboTV, YouTube TV, Hulu + Live TV, or DirecTV Stream.
YouTube TV also provides a 20-minute free preview without requiring registration.
Fans outside the regional broadcast areas can watch the game on YouTube’s NFL Sunday Ticket, starting at $34.50 per month.
New Orleans Saints vs. Buffalo Bills
Date: Sunday, September 28, 2025
Time: 1:00 PM Eastern
Venue: Highmark Stadium, Orchard Park, NY
TV: CBS
Streaming: CBS and CBS Sports apps and websites, Paramount+
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